Table 1.

Common crystallographic intermolecular hydrogen bonds and contacts in the CoV-2 and CoV complexes

CoV-2	CoV	hACE2	Hydrogen bond	Contact
Residue	Residue	Residue	CoV-2/CoV	CoV-2/CoV
Y449	Y436	D38	sc-sca	–
Y449	Y436	Q42	sc-sc	–
Y453	Y440	H34	–	p-npa
F456	L443	T27	–	np-npa
F486	L472	L79	–	np-np
N487	N473	Q24	sc-sc	–
N487	N473	Y83	sc-sc	–
Y489	Y475	T27	–	np-np
Y489	Y475	F28	–	p-np
Y489	Y475	K31	–	np-np
Y489	Y475	Y83	sc-sc	–
G496	G482	K353	–	p-np
Q498	Y484	Y41	–	np-np
Q498	Y484	Q42	–	p-p
T500	T486	Y41	sc-sc	–
T500	T486	N330	–	np-np
T500	T486	D355	–	p-p
T500	T486	R357	–	np-p
N501b	T487	Y41	mc-sc	–
G502	G488	K353	sc-mc	–
G502	G488	G354	–	np-p
Y505	Y491	E37	sc-sc	–
Y505	Y491	K353	–	np-np
Y505	Y491	G354	–	np-p

Structurally equivalent residues in the CoV-2 and CoV RBMs are included in the same row.

^a“sc” and “mc” denote hydrogen bonds involving side-chain and main-chain atoms, respectively; “np” and “p” denote contacts involving nonpolar and polar moieties.

^bDesigned position.