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. 2021 May 3;2021:6654887. doi: 10.1155/2021/6654887

Figure 2.

Figure 2

The main regulatory mechanism of ferroptosis. Abbreviations: Cys: cystine; Glu: glutamate; GSH: glutathione; GSSG: glutathione disulfide; GPX4: glutathione peroxidase 4; L-OOH: lipid hydroperoxides; L-OH: the alcohol of lipid hydroperoxides; PUFAs: polyunsaturated fatty acids; PE: phosphatidylethanolamine; LOX: lipoxygenase; DPP4: dipeptidyl peptidase-4; CDKN1A: cyclin-dependent kinase inhibitor 1A; SAT1: spermidine/spermine N1-acetyltransferase 1; GLS2: glutaminase 2.