Figure 6.

KLK1 could upregulate NO/cGMP signal and inhibit fibrosis in the prostate of aged rats. (a, b, e, and h) NO content, cGMP content, ADMA content, and cAMP content normalized to total protein concentration of rat prostate samples. (c, f, and i) Representative Western blot results of eNOS, DDAH2, COX-2, PTGIS, TGF-β1, RhoA, and ROCK1 in prostates of all three groups. (d, g, and j) The expression levels of above-mentioned proteins with β-actin as the loading control in all three groups. For each group, values are presented as the mean ± SD of 10 rats per group. ^∗P < 0.05, ^∗∗P < 0.01 (aTGR vs. aWTR). ^##P < 0.01 (aWTR vs. yWTR).