Table 3.
Summary of study characteristics extracted from included clinical trials.
| Author | Number | Mean birth weight | Mean time after birth | Dose of MSC | Method | Stem cell source | Aim |
|---|---|---|---|---|---|---|---|
| Chang (2014) | 9 | 630-1030 g | 7-14 d | (1) Low dose: 1 × 107 cells/kg (2) High dose: 2 × 107 cells/kg |
IT | Allograft transplantation | Assess the safety and feasibility of allogeneic hUC-MSC transplantation in preterm infants |
| Powell (2019) | 12 | 500-1000 g | No surfactant within 24 hours | (1) Low dose: 1 × 107 cells/kg (2) High dose: 2 × 107 cells/kg |
IT | Allograft transplantation | Assess the safety of intratracheal administration of hUC-MSCs into premature infant patients at high risk for BPD |