Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 29;53(5):618–629. doi: 10.1038/s41588-021-00841-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 6 — a, Different types of Hi-C ligation products. Ligation of two interacting restriction fragments can occur in 4 different fragment orientation (head-to-head, tail-to-tail, head-to-tail and tail-to-head). These 4 products can be identified by the Hi-C read orientation, as indicated, and are expected to occur with equal frequency (25% for each type). Self-circularized (partial) digestion products, or unligated linear fragments are also produced in Hi-C and are uninformative. These two products are characterized by the two Hi-C read orientations for each molecule: (-) and (+) for self-circularized molecules and (+) and (-) for unligated molecules. b, Genome-wide P(s) plots for each of the 4 Hi-C read orientations for coccoid-enriched cultures. For distances below 2–3 kb uninformative Hi-C dominate, while for genomic distance over 2–3 kb all 4 read-orientation occur with equal frequency. Hi-C data was mapped against Smic1.0. c, Genome-wide P(s) plots for each of the 4 Hi-C read orientations for mastigote-enriched cultures. For distances below 2–3 kb uninformative Hi-C dominate, while for genomic distance over 2–3 kb all 4 read-orientations occur with equal frequency. Hi-C data was mapped against Smic1.0.