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. 2021 Apr 29;53(5):618–629. doi: 10.1038/s41588-021-00841-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, Hi-C interaction maps for a section of chromosome 19 (Smic1.0; bins size 10 kb) for cells treated with DMSO (control, left) or triptolide (TRP) and DRB (right). Cells were treated with 25 μM TRP + 50 μM DRB or 200 μM TRP + 400 μM DRB. Both treatments produced similar results, and Hi-C data obtained with the two treatments were pooled. Arrows indicate positions of domain boundaries that are visible in control cells and that disappear in cells treated with triptolide and DRB. b, Hi-C data (observed/expected) for DMSO-treated cells, aggregated around domain boundaries (±500 kb; n = 441, left panel), convergent sites (n = 280; middle panel) and divergent sites (n = 517; right panel). Bin size: 10 kb. Data are log₁₀(observed interaction frequency/expected interaction frequency). c, Hi-C data (observed/expected) for triptolide + DRB-treated cells, aggregated around domain boundaries (±500 kb; n = 441, left panel), convergent sites (n = 280; middle panel) and divergent sites (n = 517; right panel). Bin size: 10 kb. Data are log₁₀(observed interaction frequency/expected interaction frequency). d, Change in chromatin interactions around domain boundaries (±500 kb; n = 441, left panel), convergent sites (n = 288; middle panel) and divergent sites (n = 517; right panel). Shown is log₂[(TRP + DRB)/DMSO]. Bin size: 10 kb.