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. 2021 Apr 19;53(5):742–751. doi: 10.1038/s41588-021-00836-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — The symbol s1-s4 in the x-axis represents the four developmental stages of flounder, including the pre-metamorphic stage, the pro-metamorphic stage, the metamorphic climax stage, and the post-metamorphic stage, respectively. The y-axis represents the gene expression difference across the left-right axis of flounder, as indicated by FPKM values. The minima, maxima, centre, and the upper and lower bounds of box represent the maximum, minimum, median value, upper and lower quartile, respectively. Each colored dot represents one gene in WNT, RA, or NODAL signal pathway, or gene that associated with pigmentation that are equivalent to those indicated in Fig. 4d in the main text.