Table 2.
Putative virulence genes conserved in R. amblyommatis.
| Putative virulence factorsa | Gene numbers in str. GAT-30Vb | Gene numbers in str. An13c | Gene numbers in str. Ac37d | % identity to R. rickettsiie | Predicted virulence functionsf |
|---|---|---|---|---|---|
| Adr1 | MCE_08 045 | A3305_02 145 | AL573_07 330 | 94.63% | Complement resistance |
| Adr2 | MCE_08 050 | A3305_02 150 | AL573_07 335 | 95.09% | Complement resistance |
| Pat1 | MCE_06 135 | A3305_00 385 | AL573_05 575 | 88.57% | Phagolysosome escape |
| RickA | MCE_06 070 | A3305_00 325 | AL573_05 520 | 91.02% | Actin-based motility |
| RARP2 | MCE_06 205 | A3305_00 455 | AL573_05 645 | 90.13% | Effector protein of T4SS |
| Sca0 | MCE_07 995 | A3305_02 110 | AL573_07 295 | 86.65% | Host cell adhesion |
| Sca1 | MCE_00 840 | A3305_02 870 | AL573_00 730 | 87.67% | Host cell adhesion |
| Sca2 | MCE_01 310 | A3305_03 305 | AL573_01 175 | 86.69% | Actin-based motility |
| Sca4 | MCE_04 250 | A3305_06 025 | AL573_03 910 | 93.89% | Cell-to-cell spread |
| Sca5 | MCE_07 010 | A3305_01 180 | AL573_06 365 | 90.27% | Host cell adhesion |
a
Annotated virulence factors shown to be involved in spotted fever pathogenesis in animal infection models.
b
Gene numbers in R. amblyommatis strain GAT-30V (GenBank: CP003334.1).
c
Gene numbers in R. amblyommatis strain An13 (GenBank: CP015012.1).
d
Gene numbers in R. amblyommatis strain Ac37 (GenBank: CP012420.1).
e
Percent identity to amino acids in R. rickettsii strain Sheila Smith (GenBank: CP000848.1).
f
Predicted virulence functions of each gene products.