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. 2021 May 10;12:2578. doi: 10.1038/s41467-021-22590-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Ribbon diagram (blue) of a monomer from the MyD88^TIR higher-order assembly structure. Structural elements are labelled sequentially in TIR domains, with the BB-loop connecting strand βB with helix αB, according to the established nomenclature¹²⁹. b–f Superposition of the MyD88^TIR SFX structure (blue), with b the MyD88^TIR MicroED structure (orange); c the monomeric MyD88^TIR X-ray crystal structure (PDB ID 4EO7; magenta); d the monomeric MyD88^TIR NMR solution structure (PDB ID 2Z5V; green); e the crystal structure of the TIR domain of the Toll-related receptor TRR2 from the lower metazoan Hydra vulgaris (PDB ID 4W8G; yellow); and f the MAL^TIR higher-order assembly cryo-EM structure (PDB ID 5UZB; red).