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. 2021 May 10;11:264. doi: 10.1038/s41398-021-01376-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — (1) FreeSurfer Brainstem Substructures. (2) The pons mask (green) was trimmed, keeping the most dorsal 5 voxels. (3) The resulting mask was overlaid on the time-weighted summated PET-image. (4) Median raphe is the structure with highest [¹¹C]MADAM binding within the boundaries of the trimmed pons mask; the most intense PET-voxel was located and in an iterative process the voxel with highest intensity adjacent to the initial voxel was added until 65 voxels were collected. (5) The resulting mask overlaid on the MR-image. The same procedure was used to delineate a region preferentially sampling dorsal raphe except for using the midbrain mask (yellow in panel 1) and 116 voxels.