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. 2021 May 10;11:264. doi: 10.1038/s41398-021-01376-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — In A MADRS-S measurements during the course of ICBT. Each cell represents one patient, (n = 17), letters in lower left corner corresponds to the letters in Fig. 1, numbers in parenthesis is CGI-I. In B longitudinal [¹¹C]MADAM data (n = 16) for the composite region, PET1 (baseline) and PET2 (after treatment). Right panel shows difference scores between scans. In C mean parametric image of patients at baseline (upper image) and after treatment (lower image; n = 16), see Supplement 3 for a 3D movie of the same data. In D longitudinal data, median raphe, BP_ND at PET1 (baseline, left) and PET2 (after treatment, right). In E cross-sectional data, median raphe, BP_ND for patients with MDD at baseline (left) and healthy controls (right). In F cross-sectional [¹¹C]MADAM data (n = 17 + 17) for the composite region, comparing patients with MDD at baseline to matched healthy controls. Right panel shows difference scores between matched pairs.