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. 2020 Oct 31;43(2):985–1001. doi: 10.1007/s11357-020-00287-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Plasma levels of GDF15, FGF21 and HN in healthy and pathological conditions. Circulating plasma levels of GDF15 (a), FGF21 (b), and HN (c) in centenarians’ offspring (OFF), healthy controls (HC), T2D patients without complications (T2DnC) and T2D patients with complications (T2DC), and Alzheimer’s disease patients (AD). Data are expressed as mean ± SE. p values were determined by Kruskal-Wallis test with Bonferroni correction