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. 2020 Oct 31;43(2):985–1001. doi: 10.1007/s11357-020-00287-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Conceptual framework of the mediation analysis. Direct acyclic graph showing the association between GDF15 and estimated glomerular filtration rate (eGFR), where uric acid was considered as mediator. *p < 0.05; **p < 0.01 for standardized bootstrapped (10,000 samples) total, direct and indirect effect size. In brackets, the standard errors for total and direct effects and the 95% CI for indirect effect are reported. The mediation procedure is described in the “Material and methods” section