Table 2.

Circulating levels of FGF21 in healthy controls (HC) and T2D patients subdivided by BMI. The comparison is shown between HC and T2D within the same BMI subgroup (p values reported on the right, Mann-Whitney test) and among the different BMI subgroups (p values reported below, Kruskal-Wallis test). Data are expressed as mean values ± standard error (SE). Significance level of p value is < 0.05. n.s., not significant

Mean ± SE	Normal weight (BMI range: 18.5 to 24.99)
	HC (n°  = 22)	T2D (n° = 40)	p value
BMI	23.16 (± 0.35)	23.16 (± 0.35)
FGF21 (pg/mL)	258.32 (± 35.50)	286.59 (± 33.88)	n.s.
Mean ± SE	Overweight (BMI range: 25 to 29.99)
	HC (n° = 49)	T2D (n° = 123)	p value
BMI	27.41 (± 0.20)	27.27 (± 0.12)
FGF21 (pg/mL)	349.20 (± 40.66)	352.23 (± 28.35)	n.s.
Mean ± SE	Obese (BMI > 30)
	HC (n° = 21)	T2D (n° = 92)	p value
BMI	33.45 (± 0.89)	33.71 (± 0.32)
FGF21 (pg/mL)	377.72 (± 29.12)	412.95 (± 22.42)	n.s.
	p value 0.03	p value <0.001