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Oxidized RNA nucleobases lead to altered base-pairing properties. Due to the particular reactivity of guanosine, 8-oxoG has been demonstrated to be a common oxidation product, both in disease tissue and in experimental models treated with oxidizing agents. It is well known that upon oxidative stress, oxidized guanosine can pair with both cytosine and adenosine during polymerase chain reaction, thus giving rise to 8-oxoG-A mismatches
