Table 1.
Feedback loops in the causal loop diagram (Fig. 1)
| Loop | 1st variable | 2nd variable | 3rd variable |
|---|---|---|---|
| RD1 | Amyloid beta burden | Neuroinflammation | - |
| RD2 | Oxidative stress | Neuroinflammation | - |
| RD3 | Amyloid beta burden | Cerebral endothelial dysfunction | - |
| RD4 | Brain perfusion | Cerebral endothelial dysfunction | - |
| RD5 | Systemic inflammation | Morbidity burden | - |
| RD6 | Motor function | Physical activity | - |
| RD7 | Physical activity | Depressive symptoms | - |
| RD8 | Excessive alcohol use | Social relationships | - |
| RD9 | Sleep quality | Experienced stress | - |
| RD10 | Depressive symptoms | Experienced stress | - |
| RD11 | Depressive symptoms | Cognitive functioning | - |
| RD12 | Depressive symptoms | Sleep quality | - |
| RD13 | Depressive symptoms | Social relationships | - |
| RD14 | Sleep quality | Social relationships | - |
| RI1 | Oxidative stress | Neuronal dysfunction | Circadian misalignment |
| RI2 | Physical activity | Neuronal connectivity | Cognitive functioning |
| RI3 | Obesity | Motor function | Physical activity |
| RI4 | Morbidity burden | Motor function | Physical activity |
| RI5 | Brain perfusion | Physical activity | Cognitive functioning |
| RI6 | Neuronal connectivity | Cognitive functioning | Engagement in cognitively demanding tasks |
| RI7 | Morbidity burden | Daily functioning | Social relationships |
| RI8 | Physical activity | Sleep quality | Cognitive functioning |
| RI9 | Physical activity | Depressive symptoms | Social relationships |
| RI10 | Physical activity | Sleep quality | Social relationships |
| RI11 | Experienced stress | Depressive symptoms | Sleep quality |
| RI12 | Experienced stress | Sleep quality | Depressive symptoms |
| RI13 | Experienced stress | Depressive symptoms | Social relationships |
| RI14 | Social relationships | Depressive symptoms | Cognitive functioning |
| RI15 | Depressive symptoms | Sleep quality | Social relationships |
| RI16 | Depressive symptoms | Social relationships | Sleep quality |
Direct reinforcing loops (RD) consist of two variables and the indirect reinforcing loops (RI) consist of three variables