Fig. 4.

Sex- and treatment-specific effects of Rap and Rap + Met treatments on mitochondrial proteome turnover in the liver. Effects of Rap and Rap + Met treatments on log₂-fold change (FC) from control in protein content (A and B), fractional protein synthesis (C and D), and absolute protein synthesis (E and F) in specific mitochondrial components from male (A, C, and E, respectively) and female (B, D, and F, respectively). Sex-independent top significantly upregulated or downregulated enriched canonical pathways of individual proteins with significantly different synthesis rates from Con in Rap, Rap + Met, or Rap + Met versus Rap in the liver (G). b = significantly different than Rap, P < 0.05