Table 4.

Association between telomere length and the risk for incidence of at least one new frailty phenotype criterion in TSHA and ENRICA participants

	TSHA cohort		ENRICA cohort
	OR [95% CI]	p value	OR [95% CI]	p value
Model 1	0.99 [0.90–1.08]	0.76	0.96 [0.88–1.04]	0.29
Model 2	1.01 [0.92–1.11]	0.89	0.95 [0.87–1.04]	0.25
Model 3	1.01 [0.92–1.12]	0.76	0.94 [0.86–1.03]	0.16
Model 4	1.02 [0.92–1.12]	0.75	0.94 [0.86–1.03]	0.16
Model 5	1.02 [0.92–1.12]	0.75	0.93 [0.85–1.02]	0.14

The association between telomere length and the risk for incidence of a new frailty phenotype criterion was estimated by odds ratios (OR) and their 95% confidence intervals (CI, in brackets). Increase in TL by 1 kilobase was used for calculating OR. Model 1: non-adjusted model. Model 2: adjusted by age (years) and sex. Model 3: additionally adjusted by diabetes mellitus, cardiovascular disease and cerebrovascular disease. Model 4: further adjusted by education level (higher than primary school). Model 5: further adjusted by disability in basic activities of daily living