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. 2021 May 10;11:9895. doi: 10.1038/s41598-021-89180-w

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Decision tree analysis to identify the risk of in-hospital mortality. Out of 31 patients of whom serum samples were available for day 1, nine died (30%). First decision step: Patients were identified as having elevated risk when SDMA levels were ≥ 0.90 μmol/L, and moderate risk when SDMA levels were < 0.90 µmol/L. Second decision step: Additional analysis of ADMA allowed identification of patients with high risk (SDMA ≥ 0.90 µmol/L and ADMA ≥ 0.66 µmol/L (mortality, 87.5%), intermediate risk (SDMA ≥ 0.90 µmol/L or ADMA ≥ 0.66 µmol/L (mortality, 25%), or low risk (SDMA < 0.90 µmol/L and ADMA < 0.66 µmol/L (mortality, 0%).