Table 2.
Predictive power of the SOFA score, C-reactive protein levels, and pro-calcitonin levels at admission for in-hospital mortality, when analysed alone or in combination with SDMA or ADMA.
| Parameter | Mortality [%] high/intermediate1/low |
P* | Hazard Ratio for high vs. low group | p# |
|---|---|---|---|---|
| SOFA Score | 50.0/15.4 | n.a | 1.25 (0.29–5.66) | 0.760 |
| SOFA Score + SDMA | 75.0/33.3/0.0 | 0.020 | 6.31 (1.07–37.16) | 0.042 |
| SOFA Score + ADMA | 77.8/11.1/9.1 | 0.123 | 2.38 (0.46–11.19) | 0.528 |
| C-reactive protein | 57.1/5.9 | n.a | 3.47 (0.70–12.01) | 0.176 |
| C-reactive protein + SDMA | 77.8/28.6/0.0 | 0.005 | 7.95 (1.57–40.25) | 0.0012 |
| C-reactive protein + ADMA | 77.8/22.2/0.0 | 0.039 | 5.04 (0.81–31.28) | 0.083 |
| Pro-calcitonin | 61.5/5.6 | n.a | 3.54 (0.84–14.90) | 0.085 |
| Pro-calcitonin + SDMA | 87.5/25.0/0.0 | 0.004 | 10.37 (2.02–53.35) | 0.005 |
| Pro-calcitonin + ADMA | 87.5/20.0/0.0 | 0.017 | 5.58 (0.93–33.53) | 0.060 |
| Leukocytes | 58.3/10.5 | n.a | 4.71 (1.15–16.09) | 0.032 |
| Leukocytes + SDMA | 100.0/27.3/0.0 | < 0.0001 | 25.97 (4.49–150.30) | 0.0003 |
| Leukocytes + ADMA | 85.7/27.3/0.0 | 0.012 | 8.30 (1.42–48.38) | 0.019 |
1 Mortality of the subgroups is given for the dichotomized SOFA score, C-reactive protein, and pro-calcitonin values when analyzed alone (no intermediate risk group), as well as for the highest risk group (traditional risk marker high plus SDMA/ADMA high), the intermediate risk group (traditional risk marker or SDMA/ADMA high), and lowest risk group (traditional risk marker plus SDMA/ADMA low). *P denotes statistical significance level in logrank test for trend across all risk groups. #p denotes statistical significance level for the hazard ratio of the high vs. low-risk groups. SOFA, sequential organ failure assessment; SDMA, symmetric dimethylarginine; ADMA, asymmetric dimethylarginine.