Skip to main content
. 2021 Mar 19;124(10):1670–1679. doi: 10.1038/s41416-021-01297-x

Fig. 3. LDHA is required for viability and survival.

Fig. 3

a Suppression of LDHA triggered a time- and dose-dependent decrease in viability. b Clonogenic surviving fraction. c Suppression of LDHA modestly increased radiation effectiveness, measured using clonogenic surviving fraction. d Suppression of LDHA increased intra-cellular ROS level. Activation of shLDHA constructs by DOX increased ROS level in 22A-shLDHA-5 clone at 24 and 48 h. All experiments were performed at least triplicate, and every condition was tested at least in triplicate. Error bars represent standard deviation. *P < 0.05 compared with control condition.