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. 2021 Mar 19;124(10):1670–1679. doi: 10.1038/s41416-021-01297-x

Fig. 5. LDHA activity is required to neutralise radiation effects.

Fig. 5

a Suppression of LDHA activity resulted in a significant increase in tumour growth inhibition when combined with radiation. Cessation of suppression resulted in tumour volume stability. LDHA suppression was induced at day 12 and combined with radiation treatments (5 Gy/day × 2 days) given on days 15 and 18 after cell injection. b Suppression of LDHA significantly prolonged median survival time. c Suppression of LDHA resulted in decreased tumour LDH activity. d Suppression of LDHA led to reduced lactate production in tumour xenografts. e Western blots demonstrating suppression of LDHA protein levels in tumours following treatment with DOX. Data for a are presented as means with error bars representing standard deviations. *P < 0.05 compared with control condition.