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. 2021 Mar 15;124(10):1621–1622. doi: 10.1038/s41416-021-01314-z

Fig. 1. Role of m6A modification in sorafenib resistance by modulating autophagy in hepatocellular carcinoma (HCC).

Fig. 1

a The m6A “writer” METTL3 sensitises HCC cells to sorafenib through stabilising forkhead box class O3 (FOXO3) in an m6A-dependent manner. m6A is deposited on FOXO3 mRNA by METTL3 and translated by YTHDF1, further increased FOXO3 downregulates the transcription of autophagy-related genes, including ATG3, ATG5, ATG7, ATG12, and ATG16L1, thereby, inhibition of autophagy promotes the death of HCC cells. b Depletion of METTL3 and FOXO3 promote autophagy associated sorafenib resistance in HCC.