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. 2021 May 10;11:9915. doi: 10.1038/s41598-021-89308-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Decrease of Paneth cell number and cryptdin-1 expression in CSDS model. (a) Paneth cell number per crypt. (b) Representative confocal images of Crp1 (green) with DAPI (blue) of crypt sections. Scale bars indicate 10 µm. (c) Crp1 positive granule area per crypt. The data of a, c were shown as mean ± SE of six independent experiments in each group. Mann–Whitney U tests were used to compare the data. **P < 0.01.