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. 2021 May 10;11:9915. doi: 10.1038/s41598-021-89308-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in fecal metabolites correlated with Crps in each group. (a) Metabolites significantly correlated with Crps and microbiota (blue metabolites in Table 3). (b) Metabolites significantly correlated with Crps (Metabolites in Table 2 other than those shown in (a)). All data were shown as mean ± SE of six independent experiments in each group. Tukey's tests were used to compare the data. *P < 0.05; **P < 0.01.