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. 2021 Mar 15;124(10):1680–1689. doi: 10.1038/s41416-021-01307-y

Fig. 1. Distribution of tertiary lymphoid structures (TLS) in tissue and across TNM stages of NSCLC.

Fig. 1

a–d Examples of different levels of TLS in resected primary tumours using CD8 (brown)/cytokeratin (CK, yellow) antibodies. Cytotoxic T cells labelled with CD8 and epithelial cells with CK. a No, b low, c moderate and d high TLS based on semi-quantitative model of scoring. TLSs with germinal centres (GC+ TLS, red circle) and without germinal centres (blue circle) are indicated. e, f Box-plots showing the distribution of total TLS (e) and GC+ TLS (f) count across TNM stages (stage I, n = 213; stage II, n = 159; stage III, n = 118) in NSCLC. Statistical analysis was performed with Kruskal–Wallis and Dunn’s multiple comparison tests. n.s. not significant, * adjusted P < 0.05.