Table 1.
Cox regression analysis summarising significant independent prognostic factors for DSS in the overall cohort using different scoring models.
| Model 1 (SQ-TLS) | HR (95% CI) | P | Model 2 quantitative TLS) | HR (95% CI) | P | Model 3 (quantitative GC+ TLS) | HR (95% CI) | P |
|---|---|---|---|---|---|---|---|---|
| TLS | <0.001 | <0.001 | ||||||
| No TLS | 1 | 0–2 | 1 | Low | 1 | |||
| Low | 0.7 (0.5–1.05) | 0.09 | 3–8 | 0.9 (0.6–1.3) | 0.8 | High | 0.5 (0.4–0.7) | <0.001 |
| Medium | 0.5 (0.36–0.8) | 0.003 | 9–16 | 0.7 (0.5–1.1) | 0.1 | |||
| High | 0.3 (0.1–0.5) | <0.001 | 17–106 | 0.3 (0.1–0.5) | 0.001 | |||
| TNM | <0.001 | <0.001 | <0.001 | |||||
| I | 1 | 1 | 1 | |||||
| II | 1.6 (1.1–2.3) | 0.01 | 1.6 (1.1–2.3) | 0.009 | 1.5 (1.1–2.2) | 0.03 | ||
| III | 4.02 (2.8–5.7) | <0.001 | 4.2 (2.8–5.7) | <0.001 | 4.1 (2.8–5.7) | <0.001 | ||
| Sex | ||||||||
| Male vs. female | 1.5 (1.05–2.05) | 0.02 | 1.5 (1.1–2.05) | 0.02 | 1.4 (1.03–1.9) | 0.03 | ||
| ECOG | 0.01 | 0.006 | 0.007 | |||||
| 0 | 1 | 1 | 1 | |||||
| 1 | 1.5 (1.1–2.1) | 0.004 | 1.6 (1.2–2.2) | 0.002 | 1.6 (1.2–2.1) | 0.003 | ||
| 2 | 1.6 (0.8–3.03) | 0.1 | 1.7 (0.9–3.2) | 0.1 | 1.6 (0.8–2.9) | 0.1 | ||
| Histology | 0.06 | 0.08 | 0.1 | |||||
| LUSC | 1 | 1 | 1 | |||||
| LUAD | 1.4 (1.06–1.9) | 0.02 | 1.4 (1.03–1.8) | 0.03 | 1.3 (1.02–1.8) | 0.03 | ||
| Others | 1.1 (0.3–4.8) | 0.8 | 1.2 (0.3–4.9) | 0.8 | 0.8 (0.2–3.4) | 0.7 | ||
| Vascular invasion | ||||||||
| Yes vs. no | 1.9 (1.3–2.7) | 0.001 | 1.8 (1.3–2.6) | 0.001 | 1.9 (1.4–2.7) | <0.001 |
SQ semi-quantitative, HR hazard ratio, Cl confidence interval, ECOG Eastern Cooperative Oncology Group, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma. Significant p-values in bold (threshold p < 0.05).