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. 2021 May 10;11:9842. doi: 10.1038/s41598-021-89052-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced follicle growth of si-Figla in mature mice. (a) The expression of Figla was significantly weaker in si-Figla (1# left, 2# right) secondary follicle oocytes than in the control (n = 3, for each group). (b, c) The diameters of follicles before culture (upper graph) and after 12 days of in vitro culture (lower graph) are shown. The diameter of si-Figla was significantly smaller than the control after culture in mature mice (b), whereas no significant difference was observed in premature mice (c). The diameters of mature mouse follicles before culture were 114.6 ± 8.69 µm (n = 25) in control, 117.8 ± 8.98 µm (n = 25) in siFigla1#, and 115.4 ± 11.35 µm (n = 25) in si-Figla2#, whereas diameters after culture were 452.1 ± 123.2 µm (n = 25) in control, 364.7 ± 100.4 µm (n = 25) in si-Figla1#, and 276.2 ± 162.8 (n = 25) µm in si-Figla2#. The diameters of premature mice follicles before culture were 119.0 ± 7.31 µm (n = 26) in control, 119.4 ± 8.07 µm (n = 24) in si-Figla1#, and 117.9 ± 11.0 µm (n = 25) in si-Figla2#, whereas diameters after culture were 508.0 ± 110.5 µm (n = 26) in control, 495.8 ± 113.2 µm (n = 24) in si-Figla1#, and 453.2 ± 117.4 µm (n = 25) in si-Figla2#. (d) Representative pictures of follicles after 12 days of in vitro culture, (i)–(iii) mature mice, (iv)–(vi) premature mice, (i), (iv) control, (ii), (v) si-Figla1#, (iii), (vi) si-Figla2#. Scale bars, 100 µm.