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. 2021 May 10;11:9842. doi: 10.1038/s41598-021-89052-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pursuit of downstream genes of Figla. (a) Venn diagram of DEGs in two comparisons, si-Figla1# vs control (1#) and si-Figla2# vs control (2#). Four samples for each were compared. In total, 306 genes were up-regulated and 661 genes were down-regulated in these two si-Figlas. (b) Schematic of transcripts and phenotypes of the present study and GSE 139966. (c) Schematic of the hypothetical model of Figla functions in folliculogenesis. Figla may regulate the follicle growth of secondary follicles by down-regulating pluripotency and estrogen signaling and up-regulating VDR/RXR activation (solid line), whereas Figla may regulate primordial follicle formation through the activation of meiosis and down-regulation of pluripotency and estrogen signaling (dotted line).