Table 1.
Top 15 canonical pathways of differentially expressed genes between secondary follicle oocytes of mature and premature mice.
| Ingenuity canonical pathways | p value | Ratioa | z-scoreb | Genesc |
|---|---|---|---|---|
| Signaling by Rho family GTPases | 1.05E−07 | 0.139 | 1.8 | Acta2, Arhgef17, Arhgef4, Arhgef5, Baiap2, Cdc42ep1, Cdh8, Ezr, Fnbp1, Fos, Gnat2, Gnb1l, Gnb5, Gng3, Itga5, Jun, Map3k20, Map3k21, Mras, Nfkb2, Pak3, Pi4ka, Pip5k1b, Pkn1, Prkci, Prkcz, Rac3, Rhobtb1, Rnd1, Rnd2, Septin12, Septin2 |
| IL-8 signaling | 3.80E−07 | 0.145 | 1.964 | Braf, Ccnd2, Ccnd3, Cstb, Egf, Fnbp1, Fos, Gnb1l, Gnb5, Gng3, Gpld1, Hmox1, Itgav, Jun, Lasp1, Mpo, Mras, Pld2, Prkci, Prkcz, Rac3, Rasd1, Rasd2, Rhobtb1, Rnd1, Rnd2, Tek, Vasp, Vegfa |
| Tec kinase signaling | 3.16E−06 | 0.146 | 0.243 | Acta2, Btk, Fnbp1, Fos, Frk, Gnat2, Gnb1l, Gnb5, Gng3, Gtf2i, Itga5, Mras, Nfkb2, Pak3, Prkci, Prkcz, Rac3, Rhobtb1, Rnd1, Rnd2, Stat3, Tnfrsf21, Vav3 |
| Gαq signaling | 5.50E−06 | 0.146 | 0.775 | Adra1b, Btk, Fnbp1, Gnb1l, Gnb5, Gng3, Gpld1, Grk2, Hmox1, Mras, Nfatc2, Nfkb2, Nfkbia, Nfkbid, Plcb1, Pld2, Ppp3ca, Prkci, Prkcz, Rac3, Rhobtb1, Rnd1, Rnd2 |
| NRF2-mediated oxidative stress response | 1.23E−05 | 0.132 | 1.291 | Acta2, Cat, Cbr1, Dnajb1, Dnajb14, Dnajb2, Erp29, Fos, Ftl, Gsr, Gstm1, Gsto1, Herpud1, Hmox1, Jun, Junb, Keap1, Mras, Nqo2, Prdx1, Prkci, Prkcz, Rasd1, Rasd2 |
| PI3K signaling in B Lymphocytes | 2.34E−05 | 0.145 | 1 | Btk, Card10, Cd81, Fos, Inpp5d, Jun, Mras, Nfatc2, Nfkb2, Nfkbia, Nfkbid, Plcb1, Plce1, Plekha2, Ppp3ca, Prkci, Prkcz, Rasd1, Rasd2, Vav3 |
| Relaxin signaling | 2.57E−05 | 0.14 | 2.309 | Braf, Fos, Gnat2, Gnb1l, Gnb5, Gng3, Gucy1a1, Gucy2c, Jun, Mras, Nfkb2, Nfkbia, Nfkbid, Nos2, Pde10a, Pde1a, Pde1b, Pde1c, Prkcz, Smarcc2, Vegfa |
| TNFR1 signaling | 3.47E−05 | 0.22 | 1.508 | Casp8, Fos, Jun, Naip1, Nfkb2, Nfkbia, Nfkbid, Pak3, Ripk1, Tradd |
| Pyrimidine ribonucleotides de novo biosynthesis | 5.75E−05 | 0.227 | 1.265 | Ak7, Cad, Cmpk2, Ctps2, Entpd1, Nme2, Nme3, Nme4, Slc25a42, Smarca1 |
| RhoGDI signaling | 0.000132 | 0.122 | − 0.775 | Acta2, Arhgef17, Arhgef4, Arhgef5, Cdh8, Ezr, Fnbp1, Gnat2, Gnb1l, Gnb5, Gng3, Itga5, Mras, Pak3, Pi4ka, Pip5k1b, Rac3, Rhobtb1, Rnd1, Rnd2 |
| Axonal guidance signaling | 0.000158 | 0.0909 | N/A | Adam22, Adamts3, Baiap2, Bmp5, Bmp7, Efna1, Efnb2, Egf, Epha10, Epha4, Fzd5, Gnat2, Gnb1l, Gnb5, Gng3, Itga5, Mmp17, Mras, Nfatc2, Nrp1, Pak3, Pdgfa, Pfn2, Plcb1, Plce1, Plxnc1, Ppp3ca, Prkci, Prkcz, Rac3, Rasd1, Rasd2, Rnd1, Rtn4r, Sema3a, Sema3b, Sema4c, Sema6a, Stk36, Tubb2a, Vasp, Vegfa |
| Pyrimidine ribonucleotides interconversion | 0.000219 | 0.214 | 1 | Ak7, Cmpk2, Ctps2, Entpd1, Nme2, Nme3, Nme4, Slc25a42, Smarca1 |
| Molecular mechanisms of cancer | 0.000240 | 0.0946 | N/A | Arhgef17, Arhgef4, Arhgef5, Bmp5, Bmp7, Braf, Casp8, Ccnd2, Ccnd3, Cdk15, Ctnna2, Fnbp1, Fos, Fzd5, Gab1, Gab2, Gnat2, Itga5, Jun, Lef1, Mras, Naip, Nfkb2, Nfkbia, Nfkbid, Pak3, Plcb1, Prkci, Prkcz, Rac3, Rasd1, Rasd2, Rhobtb1, Rnd1, Rnd2, Stk36 |
| Endothelin-1 signaling | 0.000251 | 0.117 | 0.447 | Abhd3, Braf, Casp8, Fos, Gab1, Gnat2, Gpld1, Gucy1a1, Gucy2c, Hmox1, Jun, Mras, Nos1, Nos2, Plcb1, Plce1, Pld2, Prkci, Prkcz, Rasd1, Rasd2, Shc3 |
| Regulation of actin-based motility by Rho | 0.000288 | 0.149 | 1.155 | Acta2, Baiap2, Fnbp1, Itga5, Pak3, Pfn2, Pi4ka, Pip5k1b, Rac3, Rhobtb1, Rnd1, Rnd2 |
N/A not available.
aRatio of listed genes found in each pathway over the total number of genes in that pathway.
bz-score positive when pathways are up-regulated in mature mice and negative when pathways are up-regulated in premature mice.
cGenes in bold are up-regulated in mature mice, while genes in normal font are up-regulated in premature mice.