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. 2021 May 10;11:9846. doi: 10.1038/s41598-021-89128-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PCA (Principle Component Analyses)—(A) and heatmap—(B), illustrating results of genome wide methylation changes in cells under treatment and controls. PCA indicates three replicates of genome wide methylation profiles of cells recovered after BTZ treatment after 10 days (red color) have significantly different methylation profile than controls (green color). Heatmap illustrating unsupervised clustering analyses of methylation changes at the most informative CpG sites in the data set verifies PCA analyses with cells recovered after BTZ treatment (red color top of chart) displaying significant hypomethylation (blue color in the heatmap) and a degree of hypermethylation (red color in the heatmap) in comparison to controls (green, top of chart).