TABLE 2.
Underlying comorbidities diagnosed by Western medicine doctors of patients who long-term used fuzi and fuzi-based formulas.
| Comorbidities | Fuzi and Fuzi-based formulasn = 28,978, n (%) | Fuzin = 20,233, n (%) | Sini Tangn = 15,286, n (%) | Jenwu Tangn = 11,177, n (%) | Mahuang-Fuzi-Hsihsin Tangn = 7,549, n (%) | Fuzi-Lizhong Tangn = 2,820, n (%) |
|---|---|---|---|---|---|---|
| Osteoarthritis | 8,971 (31.0) | 6,867 (33.9) | 5,253 (34.4) | 4,291 (38.4) | 2,126 (28.2) | 968 (34.3) |
| Peptic ulcers | 8,543 (29.5) | 6,755 (33.4) | 5,108 (33.4) | 4,119 (36.9) | 2,379 (31.5) | 1,173 (41.6) |
| Hypertension | 5,768 (19.9) | 4,242 (21.0) | 3,006 (19.7) | 2,912 (26.1) | 1,156 (15.3) | 580 (20.6) |
| COPD | 5,695 (19.7) | 4,269 (21.1) | 3,099 (20.3) | 2,754 (24.6) | 1792 (23.7%) | 625 (22.2%) |
| Hyperlipidemia | 4,740 (16.4) | 3,635 (18.0) | 2,737 (17.9) | 2,428 (21.7) | 1,088 (14.4) | 496 (17.6) |
| Chronic liver disease | 4,717 (16.3) | 3,641 (18.0) | 2,773 (18.1) | 2,229 (19.9) | 1,203 (15.9) | 572 (20.3) |
| Diabetes mellitus | 3,002 (10.4) | 2,260 (11.2) | 1741 (11.4) | 1,527 (13.7) | 642 (8.5) | 299 (10.6) |
| Esophageal disease | 2,577 (8.9) | 2084 (10.3) | 1,666 (10.9) | 1,435 (12.8) | 758 (10.0) | 373 (13.2) |
| Thyroid disease | 2,194 (7.6) | 1776 (8.8) | 1,396 (9.1) | 1,093 (9.8) | 591 (7.8 | 296 (10.5) |
| RA, SLE, or AS | 1901 (6.6) | 1,529 (7.6) | 1,221 (8.0) | 982 (8.8) | 539 (7.1) | 333 (8.3) |
| Cerebrovascular disease | 1871 (6.5) | 1,385 (6.8) | 1,041 (6.8) | 1,054 (9.4) | 383 (5.1) | 168 (6.0) |
| Cardiac arrhythmias | 1727 (6.0) | 1,389 (6.9) | 1,057 (6.9) | 1,006 (9.0) | 515 (6.8) | 239 (8.5) |
| Ischemic heart disease | 1,505 (5.2) | 1,195 (5.9) | 893 (5.8) | 863 (7.7) | 343 (4.5) | 163 (5.8) |
| Cancer | 1,181 (4.1) | 915 (4.5) | 662 (4.3) | 586 (5.2) | 270 (3.6) | 128 (4.5) |
| Heart failure | 744 (2.6) | 576 (2.8) | 421 (2.8) | 458 (4.1) | 159 (2.1) | 72 (2.6) |
| Chronic kidney disease | 449 (1.6) | 324 (1.6) | 207 (1.4) | 280 (2.5) | 77 (1.0) | 57 (2.0) |
Corresponding ICD-9-CM codes of each disease were listed in Supplementary Table S3. AS = ankylosing spondylitis; COPD = chronic obstructive pulmonary disease; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus.