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. 2021 Apr 27;11:627608. doi: 10.3389/fcimb.2021.627608

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Copyright © 2021 Xia, Gu, Guo, Feng, Chen, Jurat, Fu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The community structures of different microbes at the phylum level in the four groups, colors indicate distinct microbe of phylum (n = 4); (B) The microbiota structures at the genus level in the four groups, different colors denote distinct microbe of genus (n = 4); (C) Orthogonal partial least squares discriminant analysis (OPLS-DA) of the microbiota in all groups (n = 4); (D) Linear discriminant analysis effect size (LEfSe) 10 was set up with 0.05 as the alpha value for Kruskal-Wallis and Wilcoxon test and then selected OTUs with LDA scores above 3 (n = 4); (E) LDA scores greater than 3 when comparing all groups, as described above (n = 4).