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. 2021 Apr 27;12:625311. doi: 10.3389/fimmu.2021.625311

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Copyright © 2021 Haynes, Kamath, Waitz, Daugherty and Shon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Literature reported and putative autoantigens are detected in Sjogren’s syndrome samples by PIWAS. (A) PIWAS results from a comparison of Sjogren’s syndrome samples to controls against the human proteome were prioritized using outlier sum FDR as a measure of significance (y-axis, see Methods). For visualization, proteins were laid out according to chromosome location. (B) Among the top set of 11 ranked proteins, 5 are established autoantigens (Lupus La/SSB in red, centromeric proteins in blue, keratin proteins in green). (C) Strength (y) and location (x) of PIWAS scores for the Lupus La protein/SSB for Sjogren’s samples that are predicate SSB+ (n=54, purple) or predicate SSB- (n=37, orange) vs. control (n=1,157, grey). (D) Comparison of PIWAS score (y) and CENPA ELISA OD (x) for Sjogren’s samples that we tested by ELISA (n=14).