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. 2021 May 10;4:540. doi: 10.1038/s42003-021-02071-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b Representative IHC staining (a) and statistics of average optical density of FMRP (b) in matched carcinoma tissues and non-carcinoma tissues. n = 21 biologically independent samples. Scale bar (10×): 100 μm. c Western blot analysis of FMRP protein levels in 8 paired HCC tissues (T) and adjacent non-tumor tissues (NT). d Western blot analysis of FMRP in L-O2, HCCLM3, MHCC97L, and MHCC97H cells (lower panel) and quantification of the intensity relative to β-actin (upper panel). e, f Q-PCR (e) and western blot (f) analyses examined the knockdown efficiency of FMRP in FMRP-knockdown cells. g, h Transwell migration (g) and invasion assays (h) in Control and FMRP-knockdown cells. The right panel is the quantification of the left panel. Scale bar: 100 μm. The values in the graphs represent the mean of three biologically independent experiments. Error bars represent ±s.d. *P < 0.05, **P < 0.01, ***P < 0.001 by two-tailed Student’s t-test.