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. 2021 May 10;4:540. doi: 10.1038/s42003-021-02071-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Livers injected with FMRP-knockdown cells to form xenograft tumors, accompanied by a scramble and mock groups. n = 6 biologically independent samples (one mouse in the KD-FMRP group did not develop a tumor). b Image of the xenograft tumors stripped from livers in nude mice. c Weights of xenograft tumors in three groups were measured. d, e Q-RCR (d) and western blot (e) analysis of FMRP and STAT3 expression of the xenograft tumors. The values in the graphs represent the mean of three biologically independent experiments. f Representative H&E staining of metastatic lung nodules at the indicated groups. Scale bar: 100 μm. Error bars represent ±s.d. *P < 0.05, **P < 0.01, ***P < 0.001 by two-tailed Student’s t-test.