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. 2021 May 10;12:2577. doi: 10.1038/s41467-021-22881-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Heatmap showing hierarchical clustering of matrisome genes that are significantly differentially expressed between dermal papilla (DP) and pan-dermal fibroblasts (pan-DF). Z-scored expression values (rlog normalized values) of each biological replicate are indicated according to a heat gradient as shown at the bottom of the heatmap. ECM genes classified as HG-specific genes, basement membrane (BM) genes and Spondin family genes are indicated by colour bars next to each gene name. b Gene set enrichment analysis (GSEA) for HG ECM genes and basement membrane (BM) genes. Upper panel shows the results of GSEA for hair germ (HG) ECM genes and BM genes against an expression data sets of DP and pan-DF. ECM genes differentially expressed between DP and pan-DF are used. Lower panels show GSEA plots. Asterisks indicate statistical significance (<25% in FDR and <5% in nominal p value). NES normalized enrichment score, Nom. p nominal p value, FDR false discovery rate, FWER p family-wise error rate p value.