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. 2021 Apr 27;9:644346. doi: 10.3389/fcell.2021.644346

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Copyright © 2021 Zhao, Liu, Ma, Gu, Wei, Luo and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Sirt1 activator RSV attenuated mitophagy inhibition caused by Bhlhe40 in C17.2 cells. (A) C17.2 cells were double immunofluorescence-stained, with LC3-labeled autophagosomes (green) and TOMM20-labeled mitochondria (red). Scale bar = 25 μm. (B) Relative fluorescence intensities of LC3 and TOMM20 in each group (n = 3). Results are expressed as the mean ± SD. *p < 0.05 vs. pcDNA + DMSO group; ^# p < 0.05 vs. Bhlhe40 + DMSO group. (C) Western blot analysis of PINK1 in mitochondria isolated from C17.2 cells treated with different combinations of pcDNA, Bhlhe40, DMSO, and RSV. (D) Quantitation of PINK1 protein (n = 3). Results are expressed as the mean ± SD. ^∗p < 0.05 vs. pcDNA + DMSO group; ^#p < 0.05 vs. Bhlhe40 + DMSO group.