Figure 5.

Clustergram of associations of significantly enriched disease pathways with proteins upregulated in clinically defined (A) converter CSF and (B) non-converter CSF. The proteins upregulated in converters were consistent with viral infection, retinal damage, and MS disease pathways while the proteins upregulated in non-converters suggest atypical rheumatoid arthritis presentation. Red squares represent a significant enrichment of the identified gene (rows) with a given pathological pathway (columns) while white squares represent no significant interaction. Fisher exact test, corrected P-values <0.05 were considered significant. Clinically defined converter n = 22, clinically defined non-converter n = 32.