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. 2021 Apr 27;12:657329. doi: 10.3389/fimmu.2021.657329

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Copyright © 2021 Pelosi, Besi, Tumino, Merli, Quatrini, Li Pira, Algeri, Moretta and Vacca

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specific immuno-modulatory genes are differentially expressed in mobilized PMN-MDSCs. (A) Heat-map of the top up-regulated and down-regulated genes in PMN-MDSCs, based on the filter FC ≥10 or ≤-10; FDR adjusted p-value ≤ 0.05. Red squares indicate up-regulated genes; blue squares down-regulated genes in mobilized PMN-MDSCs. Each row represents a gene; each column represents individual samples analyzed by microarray (control: c#1–5; mobilized: m#1–8). Specific genes selected for further analysis are highlighted. (B) Real time PCR analysis on the samples used for microarray for the indicated genes. Values were calculated with ΔCt method. 18S was used as endogenous control. Bars indicate SD. *p-value ≤ 0.05; **p-value ≤0.01 (Mann–Whitney test).