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. 2021 Apr 27;12:657329. doi: 10.3389/fimmu.2021.657329

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Copyright © 2021 Pelosi, Besi, Tumino, Merli, Quatrini, Li Pira, Algeri, Moretta and Vacca

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prolonged survival and altered chemo-attraction of mobilized PMN-MDSCs. (A) Percentages of PMN-MDSC live cells (PI^-) along 6 days of non-mobilized (PMN-MDSCs ctrl, red square line) and mobilized (PMN-MDSCs mob, blue dots line) donors. ***p-value < 0.001 (two-way ANOVA test, n = 3). (B) Percentages of live (Annexin V^- and PI^-, blue), early apoptotic (Annexin V⁺ and PI^-, green), late apoptotic (Annexin⁺ and PI⁺, red), and necrotic (Annexin V^- and PI⁺, black) control (left) and mobilized (right) PMN-MDSCs measured by flow cytometry after 24 h of culture. *p-value ≤ 0.05; (Mann–Whitney test, n = 4). (C) Numbers of migrated NK cells after 1 h of culturing in conditioned medium derived from pre- and post-mobilized PMN-MDSC, in the presence or not of anti-CCL4 blocking antibody. *p-value ≤ 0.05; (Mann–Whitney test, n = 4).