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. 2021 Jan 21;59(2):e02510-20. doi: 10.1128/JCM.02510-20

FIG 2.

FIG 2

Detection of IgG antibodies against SARS-CoV-2 in participant-derived serum and oral fluid samples collected from participants who previously tested negative or positive for COVID-19 by an oral-fluid PCR test. Receiver operating characteristic (ROC) curves represent sensitivity and specificity of each test. Manufacturer-provided cutoff values are represented by a horizontal dashed line. N.C. = negative control; P.C. = positive control. (A) With an S/CO ratio cutoff of 1.1, the EuroImmun COVID-19 antibody detection kit was 93.94% sensitive and 100% specific with an area under the ROC curve (AUC) of 0.9798. (B) The Gold Standard Diagnostics COVID-19 antibody detection kit was 78.79% sensitive and 100% specific with an AUC of 0.9543. (C) With an S/CO ratio cutoff of 1.0, the OraSure Technologies COVID-19 ELISA kit was 90.91% sensitive and 100% specific with an AUC of 0.9962.