TABLE 2.
Comparison between the IS6110 real-time PCR and microbiological culture in relation to the presence or absence of anatomic lesions compatible with bTB
| PCR resulta | Culture result |
Diagnostic performance |
||||||
|---|---|---|---|---|---|---|---|---|
| No. positive | No. negative | Total no. | Sensitivity (% [95% CI]) | Specificity (% [95% CI]) | Predictive value (% [95% CI]) |
Agreement (95% CI) | ||
| Positive | Negative | |||||||
| VL | 97.74 (95.40–99.09) | 71.43 (61.42–80.10) | 91.54 (88.78–93.67) | 90.91 (82.63–95.46) | 0.75 (0.67–0.82) | |||
| No. positive | 303 | 28 | 331 | |||||
| No. negative | 7 | 70 | 77 | |||||
| Total no. | 310 | 98 | 408 | |||||
| NVL | 82.14 (63.11–93.94) | 97.63 (95.98–98.73) | 63.89 (50.16–75.67) | 99.08 (97.98–99.58) | 0.70 (0.58–0.83) | |||
| No. positive | 23 | 13 | 36 | |||||
| No. negative | 5 | 536 | 541 | |||||
| Total no. | 28 | 549 | 577 | |||||
a
VL, visible lesions; NVL, nonvisible lesions.