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. Author manuscript; available in PMC: 2022 Jan 15.
Published in final edited form as: Arch Biochem Biophys. 2020 Dec 1;697:108702. doi: 10.1016/j.abb.2020.108702

Figure 4. Advantages of brain penetrating KMO inhibitors.

Figure 4.

Brain penetrating KMO inhibitor transferred into brain and activated by esterase. The activated KMO inhibitor suppresses the activity of KMO in brain, leading to the decrease of neurotoxic 3-HK and increase of neuroprotective KYNA. While the non-brain penetrating inhibitors act in the periphery, raising levels of L-KYN in the blood. The L-KYN will be transported to brain and converted to neuroprotective KYNA.