Skip to main content
. 2021 Apr 27;9:667800. doi: 10.3389/fcell.2021.667800

FIGURE 4.

FIGURE 4

MiR-107 regulated proliferation, apoptosis, and invasion of DLBCL cells. (A) QRT-PCR analysis of miR-107 in DLBCL cell lines and controls. PBMCs of healthy donors were used as control. (B) QRT-PCR analysis of transfection efficiency in OCI-LY3 transfected with miR-107 Agomir and OCI-LY8 transfected with miR-107 Antagomir. (C,D) MiR-107 overexpression inhibited while miR-107 downregulation promoted cell proliferation of DLBCL cell lines. (E–H) MiR-107 overexpression promoted while miR-107 downregulation inhibited cell apoptosis of DLBCL cell lines (E–G). Doxorubicin induced cell apoptosis, which could be reversed by miR-107 downregulation (E,H). (I–K) MiR-107 overexpression was inhibited while miR-107 downregulation promoted cell invasion of DLBCL cell lines. (L) Representative images of tumors in OCI-LY8 xenograft mice transfected with miR-107 Agomir or Agomir NC. Data are mean ± s.d., n ≥ 3. *p < 0.05, **p < 0.01, and ***p < 0.001. PBMCs, peripheral blood mononuclear cells; TEM, transmission electron microscopy.