TABLE 1.

MiR-107 performed as a diagnostic, prognostic indicator, and participated in cancer progression.

Cancer type	Expression	Functions and mechanisms
Breast cancer	↓	Inhibits cell proliferation, cell-cycle and invasion through BDNF (Ai et al., 2018)
	↓	Inhibits cell proliferation, colony formation, migration and invasion and promotes apoptosis through targeting SIAH1 (Zhang et al., 2016)
	↓	Relates with histological grade index of ER-positive breast cancer (Tsunoda et al., 2018)
	↑	Performs predictive role in the triple-negative breast cancer (Hong et al., 2020; Terkelsen et al., 2020)
Gastric cancer	↑	Associates with tumor progression characteristics and acts as an independent prognostic factor for OS and DFS (Inoue et al., 2012)
	↑	Promotes cell growth, migration, and invasion by targeting NF1 (Wang S. et al., 2016)
Lung cancer	↓	Inhibits cell proliferation, migration and arrest cell cycle by targeting TGFβR2 (Wu Z. et al., 2020)
	↓	Inhibits paclitaxel resistance, metastasis, proliferation and survival through Bcl-w/PI3K-AKT (Lu et al., 2017)
	↓	Inhibits cancer progression by targeting EGFR (Wang et al., 2017)
	↓	Correlates with tumor progression characteristics and inhibits cancer growth by targeting BDNF and PI3K/AKT pathway (Xia et al., 2016)
Hepatocellular carcinoma	↑	Promotes tumor progression through miR-107/CPEB3/EGFR axis (Zou et al., 2016)
Renal cell carcinoma	↓	Inhibits cell proliferation and invasion by targeting EIF5 (Song et al., 2015)
Meningioma	↓	Correlates with the increasing histopathological grade (Katar et al., 2017)
Prostate cancer		MiR-107-miR-26b-5p predict prostate cancer with AUC = 0.93 and p = 0.0012 (Lekchnov et al., 2018)
Glioblastomas	↓	MiR-107-miR-331 associate with poorer prognosis (p = 0.033) (Hermansen et al., 2017)
Colorectal cancer	↑	Induces chemoresistance through CAB39-AMPK-mTOR pathway (Liang et al., 2020) HOTAIRM1/miR-107/TDG axis regulates cell proliferation, invasion, and migration (Li et al., 2020)

↑, Upregulation; ↓, Downregulation.