Fig. 6.

Validation of SCFA mediated inhibition of Ras signaling. (A) Representative western blot of DAB2 and Shoc2 from treated compared to control livers. (B) Summary of differentially expressed DAB2 and Shoc2 from treated (n = 12) compared to control (n = 12) mice (*P < 0.01). Signal density was measured in arbitrary units. (C) Summary of proteomics and western blot data of SCFAs on Ras-related proteins in 12-month old HBxTg mouse livers. Proteins with increased expression after SCFA treatment are indicated by a triangle, and proteins decreased by SCFA treatment are indicated by circles. Proteins in the Ras pathway that were not differentially expressed by SCFA treatment are indicated by a box.