Table 2.

Summary of autoantibody binding sites on FH.

	NMO64	NMO84	NMO113	NMO210
FH	(+)	(+)	(+)	+
FH1-4	-	-	-	-
FH8-14	–	–	–	–
FH15-20	+	+	+	(+)
FH19-20	+	+	+	+
FHR-1	+	+	+	+
FHR-4B	–	–	–	–

The binding sites of the autoantibodies were determined using recombinant FH fragments containing domains 1-4 (FH1-4), 8-14 (FH8-14), 15-20 (FH15-20) and 19-20 (FH19-20), purified FH, the recombinant FH-related FHR-1 and FHR-4B proteins, the latter used as a negative control.

“(+)” indicates weak binding, “+” indicates prominent binding, “-” indicates no binding.