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. 2021 Apr 27;8:554190. doi: 10.3389/fcell.2020.554190

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Copyright © 2021 Chen, Hu, Han, Zhu, Fan, Chen, Li and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BAG2-mediated inhibition of ERα and MDM2-mediated elevation of ERβ contributes to the development of endometriosis. HESCs-NC cells were treated with overexpressed MDM2 and BAG2 with oe-NC as control, while HESCs-En cells were treated with sh-BAG2 and sh-MDM2 with sh-NC as control. (A) The mRNA expression of BAG2 and MDM2 determined by RT-qPCR. (B) The protein expression of BAG2 and MDM2 determined by western blot analysis. (C) The protein expression of ERα and ERβ determined by western blot analysis. (D) The protein expression of ERβ/ERα determined by western blot analysis. Comparisons between two groups were analyzed using independent sample t-test; *p < 0.05 vs. oe-NC treatment; ^#p < 0.05 vs. sh-NC treatment. Cell experiments were conducted in triplicate.