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Schematic diagram depicting the regulatory mechanism underlying abnormal estrogenic activity in endometriosis. The high expression of BAG2 in the endometrium reduces the degradation of ubiquitinated ERβ by CHIP, thus increasing the protein expression of ERβ. On the other hand, the high expression of MDM2 increases the degradation of ubiquitinated ERα and diminishes the protein expression of ERα, leading to a notable increase of ERβ/ERα ratio, thereby inducing endometriosis.
